Hallmarks of Aging

To impact Longevity, it is critical to address the underlying mechanisms of Aging.

9 “Hallmarks of Aging” have been identified. Each contributes to the damage that occurs and accumulates over time leading to all age-associated pathologies, and each represents an avenue for directing interventions.

The goal of Longevity Science and Medicine is to address the hallmarks of Aging, slow the advance of biological age, and delay the loss of function we experience because of aging.

There are nine cellular hallmarks of aging so far described. They can be divided into categories based on where and how they act, which helps to think about addressing them.

To impact Longevity, it is critical to address the underlying mechanisms of Aging.

9 “Hallmarks of Aging” have been identified. Each contributes to the damage that occurs and accumulates over time leading to all age-associated pathologies, and each represents an avenue for directing interventions.

The goal of Longevity Science and Medicine is to address the hallmarks of Aging, slow the advance of biological age, and delay the loss of function we experience because of aging.

There are nine cellular hallmarks of aging so far described. They can be divided into categories based on where and how they act, which helps to think about addressing them.

Genetic/Epigenetic:

  • Genomic Instability/Loss of Fidelity
  • Telomere Attrition
  • Epigenetic Changes

Cellular:

  • Cellular Senescence
  • Mitochondrial Dysfunction
  • Stem Cell Exhaustion

Extracellular/Metabolic:

  • Loss of Proteostasis (protein disorder/dysregulation/misfolding)
  • Changes in Nutrient Sensing
  • Impaired Intercellular Communication (including immune system)